Several factors are associated with an increased likelihood of developing bladder cancer: Smoking: Tobacco use is the most significant risk factor for bladder cancer. The chemicals in cigarette smoke can enter the bloodstream and accumulate in the bladder. Occupational Exposure: Some jobs, like those involving chemicals, dyes, rubber, and leather, can expose workers to substances that increase their risk of bladder cancer. Age and Gender: Bladder cancer risk increases with age, and it is more common in men than women. Family History: If someone in your family has had bladder cancer, your risk may be higher. Chronic Bladder Irritation: Repeated urinary tract infections and chronic irritation of the bladder may increase the risk.